Captain Harry Sharman says a positive performance can give “a massive boost” to the Spalding squad.
Four successive defeats since promotion have left them at the bottom of the Midlands One East table.
They face another tough test at the Memorial Field on Saturday when Ilkeston are the visitors.
Sharman, who is likely to remain sidelined until next month due to a broken nose, admitted last weekend’s home defeat to Huntingdon was “very disappointing”.
He explained: “It was so annoying because that was a game we looked at for our first win.
“But the unavailability of players, mainly through
injuries, really hampered
“We didn’t have a full squad to pick from and when bad luck is going your way, it all comes at once.
“Things are not going our way at the moment but we’re hoping our fortunes will change soon.
“It’s going to be a difficult job on Saturday. Hopefully a good performance can give us a massive boost. We’ve got nothing to lose.”
Ilkeston make the trip south after winning three of their first four games.
Sharman added: “They have always been known as a very strong, physical side.
“We are under no illusions that this is going to be a very tough game.
“We have got a few players back so hopefully that will make a difference.
“I can’t complain about last week’s performance because we were calling up players at the last minute due to injury and illness.
“We should be stronger this week and you never know what might happen.”
On his injury, Sharman added: “The operation went well and it’s just a waiting game now.
“It has been frustrating to watch from the touchline.
“It’s a real pain and I’ve got to live with it. I will probably be out of action for another three weeks so that takes us nearly into November.”
Deepings face a top-of-the-table clash with second-placed Thorney in Midlands Four East (South) as both clubs have two wins out of three.
The Green Machine beat Stamford College Old Boys 40-7 last weekend.
Bourne, without a point so far this term, head to Brackley who are in third place.