Deeping Rangers can do themselves and Spalding a favour by winning at Huningdon on Saturday.
Rangers are still hoping to finish second in the UCL Premier Division and victory at Huntongdon - the only side who can deny Spalding the title - would boost those aspirations.
Third-placed Deeping are a point above Huningdon but have played three games more.
Holbeach welcome Ash Murrell and Tom Waumsley back from suspension for the trip to Cogenhoe.
Tommy Treacher is missing though due to work commitments and Chris Shipley is injured.
In Division One, Bourne Town host Potton and look for a third successive win as they bid to climb out of the bottom two.
Dan Mason sealed a 1-0 win at Wellingborough on Tuesday that leaves them one point behind Bugbrooke St Michaels.