Two out-of-form teams will meet on Saturday.
Spalding United must get their promotion bid back on track but Loughborough Dynamo are battling against relegation.
Tulips manager Dave Frecklington said: “We have got to win on Saturday and follow that up at home to Market Drayton Town next week.
“Our form hasn’t been too bad in terms of performances but we have been punished for every minor mistake. We need to eradicate those errors.
“Last weekend at Basford United we showed we can be solid as a team with the way we are set up.
“This is a must-win game at Loughborough. Their run of defeats tells its own story but Wayne Hallcro is a manager who will get them organised.
“Both teams are out of form so something will have to give on Saturday.”
Central defenders Nathan Stainfield and Neal Spafford should be available following fitness concerns.
Left-back Adam Jackson is set to complete his return to Spalding after they had to submit a seven-day approach to Holbeach United. A deal had already been agreed between the clubs last week.
Danny Durkin has joined Loughborough following a brief spell at Spalding.
Former Tulips forward Tom Waumsley and ex-Tigers striker Jamie Clarke were the subject of ‘an urgent inquiry’ by Dynamo officials after being sent off for fighting each other in a cup game.
Loughborough’s run of 14 defeats in 16 games started with a 2-1 loss at Spalding in September.
Bradley Wells and Jenk Acar cancelled out the first-half opener by Louis Keenan.
Loughborough are second from bottom with the worst defensive record in the First Division South.